Research > BAUER FEllowS PROGRAM

Nicolas Chevrier

Host immune responses rely on the arrangement over time of molecular networks within and between cells, as well as across the body. This complexity poses a fundamental challenge to the study and manipulation of immunological processes in the context of health and disease.

Our group explores the molecular and cellular circuits forming the functional units of immune responses to microorganisms and vaccines in the natural setting of the host. To investigate the organization and rules underlying these circuits, we develop and apply experimental and computational approaches at various levels of resolution – from a single to an entire set of cellular components, or from single cells to multicellular interactions.

The driving biological questions of our research include: (i) How do immune cells develop to become functional cell-types, and how these cell-types can be identified and defined; (ii) How do these cell-types vary in their intracellular wiring, and how do they cooperate to form cellular circuits in the host; and (iii) How do microorganisms affect these processes and shape their evolution?

To address these questions and challenges, our lab strives to create an environment conducive to interdisciplinary teamwork, innovation, and learning.

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